Ibw-959z -

¹ Department of Medicinal Chemistry, University of Cambridge, UK ² Institute of Molecular Pharmacology, Shanghai Jiao Tong University, China ³ Cancer Biology Program, Universidad Nacional Autónoma de México, Mexico ⁴ Department of Pharmacology, Seoul National University, South Korea ⁵ Department of Oncology, Johns Hopkins University School of Medicine, USA

Figure 2B shows dose‑dependent suppression of phospho‑AKT and phospho‑S6 in OCI‑Ly3 cells, confirming pathway blockade. Key PK parameters are summarized in Table 3 . IBW-959z

IBW‑959z: A Novel Small‑Molecule Inhibitor of the PI3K‑δ Pathway with Potent Antitumor Activity in Pre‑clinical Models ¹ Department of Medicinal Chemistry